Figure 2.

Responsiveness to change of the RESQ-eD in the PRO Validation Study (full analysis set, N=478). Effect size of the RESQ-eD domains is shown for (a) change in mean intensity and (b) change in proportion of symptom-free days from the 7 days before randomization to treatment period. Patients were grouped by OTE at the end of treatment. Note: the effect size for worse symptoms by OTE for the Overall symptoms domain could not be computed, as all patients had 0% of symptom-free days during the 7 days prior to first dose. OTE, Overall Treatment Evaluation; PRO, patient-reported outcome; RESQ-eD, Reflux Disease Questionnaire electronic Diary.