Table 3. PAI-1, SNAI2, and E-cadherin expression in esophageal adenocarcinoma patients with respect to obesity status and tumor differentiation.
| PAI-1 expression, mean (s.e.m.) | P | SNAI2 expression, mean (s.e.m.) | P | E-cadherin expression, mean (s.e.m.) | P | |
|---|---|---|---|---|---|---|
| BMI (kg/m2) | 0.009 | 0.0693 | 0.2218 | |||
| Non-obese <30 | 1.014 (0.299) | 25.623 (3.549) | 4.546 (0.847) | |||
| Obese ≥30 | 3.691 (1.195) | 61.411 (24.515) | 3.01 (0.656) | |||
| WC (cm) | 0.0397 | 0.3097 | 0.0447 | |||
| Non-obese < 94 cm | 0.74 (0.164) | 26.659 (4.976) | 5.423 (1.232) | |||
| Obese ≥94 cm | 2.833 (0.808) | 46.731 (2.533) | 2.999 (0.468) | |||
| VFA (cm2) | 0.031 | 0.2437 | 0.0602 | |||
| Non-obese <130 cm2 | 0.529 (0.149) | 23.839 (4.134) | 5.49 (1.415) | |||
| Obese ≥130 cm2 | 2.775 (0.74) | 46.655 (14.145) | 3.155 (0.442) | |||
| Tumor diff. | 0.2782 | 0.2809 | 0.5852 | |||
| Well/moderate | 1.517 (0.492) | 73.584 (26.049) | 4.413 (0.639) | |||
| Poor | 2.467 (0.727) | 43.901 (9.297) | 3.817 (0.865) | |||
| PT | 0.1632 | 0.1796 | 0.4062 | |||
| T0–T1 | 1.569 (0.671) | 95.248 (49.316) | 3.158 (0.803) | |||
| T2–T3 | 2.634 (0.748) | 48.598 (12.171) | 4.301 (0.656) | |||
| PN | 0.5241 | 0.7256 | 0.2184 | |||
| N0 | 1.569 (0.671) | 64.717 (28.545) | 3.168 (0.569) | |||
| N1 | 2.166 (0.557) | 54.382 (15.01) | 4.581 (0.792) | |||
| Lymph inv. | 0.3262 | 0.5117 | 0.6864 | |||
| Yes | 2.26 (0.606) | 55.127 (15.53) | 3.90 (0.581) | |||
| No | 1.504 (0.561) | 77.695 (37.67) | 4.45 (1.566) | |||
| Venous inv. | 0.4164 | 0.4169 | 0.8639 | |||
| Yes | 2.299 (0.606) | 48.616 (15.974) | 3.963 (0.569) | |||
| No | 1.504 (0.561) | 72.395 (26.047) | 4.161 (1.103) | |||
| Perineural inv. | 0.6496 | 0.4895 | 0.3857 | |||
| Yes | 2.338 (0.985) | 44.257 (13.09) | 4.195 (0.949) | |||
| No | 1.9 (0.466) | 66.371 (20.284) | 3.403 (0.433) | |||
BMI, body mass index; lymph inv., lymph involvement; perineural inv., perineural involvement, expression relative to a calibrator sample (non-obese patient); pN, pathological node stage; pT, pathological tumor stage; tumor diff., tumor differentiation status; venous inv., venous involvement; VFA, visceral fat area; WC, waist circumference.