FIGURE 2.

Reduced expression of cone opsin and other phototransduction proteins in CNGA3^−/−/Nrl^−/−and CNGB3^−/−/Nrl^−/− mice. Western blot was performed to detect retinal expression of M-opsin, S-opsin, cone arrestin (CAR), and Gnat2 in CNGA3^−/−/Nrl^−/−, CNGB3^−/−/Nrl^−/−, and Nrl^−/− mice at P30. Shown are representative images (A) and the correlating densitometric analysis (B–E). Actin was probed as a loading control. Data are represented as means ± S.E. of measurements from three to four independent experiments using retinas from four to five mice. Unpaired Student's t test was used for determination of the significance (*, p < 0.05).