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Generation of Patz1 knock-out mice. A, schematic representation of the wild-type and mutant alleles and the targeting vector. St, StuI; Sp, SpeI; P, PstI; Ex., exon; Xb, XbaI. B and C, quantitative RT-PCR (B) and Western blot analysis (C) in tissues from Patz1+/+, Patz1+/−, and Patz1−/− mice, to detect PATZ expression and confirm its knock-out at both RNA and protein levels. Data express mean ± S.D. of three independent experiments.
