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. 2012 Apr 4;287(22):18562–18572. doi: 10.1074/jbc.M111.322271

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — NMUR1-mediated I_A increase was PKA-dependent. A, summary data showed the increase of I_A induced by 1 μm NMU in the presence of LY294002 (3 μm for 30 min, n = 9), U73122 (3 μm for 30 min, n = 9), GF109203X (1 μm for 30 min, n = 8), chelerythrine chloride (1 μm for 30 min, n = 7), calphostin C (50 nm, n = 7), H89 (1 μm for 30 min, n = 9), and PKI 6-22 (1 μm, intracellular applied, n = 7), respectively. B, representative current traces (left) and summary data (right) showed the effects of 20 μm forskolin on the peak amplitude of I_A in small DRG neurons (n = 9). C, NMU increased PKA activity via NMUR1. Cells were treated with either vehicle (control) or 1 μm NMU for 10 min and assayed for PKA activity as described under “Experimental Procedures.” The PKA activity data are normalized to the vehicle-treated cells as 100%. *, p < 0.05 versus control; **, p < 0.01 versus control; ##, p < 0.001 versus NMU groups.