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. 2012 Apr 4;287(22):18562–18572. doi: 10.1074/jbc.M111.322271

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — NMUR1 induces neuronal hypoexcitability in small DRG neurons. A and B, time course and summary data showed that NMU had no effects on voltage-gated Na⁺ channel currents (n = 6). Inset, representative examples of Na⁺ currents recorded before and after application of 1 μm NMU. C and D, exemplary current traces and current-voltage plot of current density of Na⁺ current versus test voltage recorded before (n = 7) and after (n = 7) 1 μm NMU. E, representative traces of firing at the resting membrane potential under control conditions, during exposure to 1 μm NMU, and washout. F, summary data comparing the average firing rates under the conditions indicated in panel E (n = 14). Cells were given +130 pA current injections. G, representative traces and summary data showed the effects of 4-AP on neuronal firing (n = 11). H, representative traces and summary data showed 4-AP abolished 1 μm NMU-induced hypoexcitability in small DRG neurons (n = 17). *, p < 0.05 versus pre-drug; **, p < 0.01 versus pre-drug.