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. 2012 Mar 28;287(22):18636–18644. doi: 10.1074/jbc.M112.345678

FIGURE 1.

FIGURE 1.

Type II topoisomerase organization. A, primary domain structure of bacterial type IIA topoisomerases. Catalytic functions are indicated with horizontal bars. Vertical black bars mark the relative locations of the catalytic tyrosine (Cat. tyrosine) and the GyrA box. B, sequence alignment between representative CTD tails. GyrA residue numbers are as follows: E. coli GyrA 838–875; M. tuberculosis (Mtube) GyrA 817–838; Vibrio cholerae (Vchol) GyrA 862–894; Yersinia pestis (Ypest) GyrA 838–891; Staphylococcus aureus (Saure) GyrA 809–886; Salmonella typhimurium (Styph) GyrA 838–878; Caulobacter crescentus (Ccren) GyrA 899–919; Xanthomonas campestris (Xcamp) GyrA 872–899; Bacillus subtilis (Bsubt) GyrA 805–821; Mycobacterium smegmatis (Msmeg) GyrA 817–854; B. burgdorferi (Bburg) GyrA 807–810; and T. maritima (Tmari) GyrA 801–804.