FIGURE 5.

Schematic of α6β4 integrin regulation of α3 and α2 integrin expression. α6β4 integrin signaling to PI3K leads to activation of AKT and its downstream effectors. Activation of this pathway leads to phosphorylation/inactivation of 4EBP1, dissociation of the complex containing initiation factor 4E (eIF4E) and 4EBP1, and ultimately, the translation of α3 integrin. Expression of α3 integrin in turn mediates the expression of α2 integrin by regulating the transcription of the α2 integrin gene and/or α2 integrin mRNA stability.