FIGURE 3.

Localization of NMDA receptor NR2A and NR2B regulatory subunits in D1- and D2-positive striatal MSNs. Immunofluorescence analysis for NR2A (upper panels) and NR2B (lower panels) subunits of NMDA receptor in drd1a-EGFP (A) or drd2-EGFP (B) transgenic mice. Confocal analysis shows a complete overlap between NR2A and NR2B subunits and the two types of dopamine receptors in the transgenic mice, indicating the presence of the two NMDA regulatory subunits in all D1 and D2 containing MSNs. Scale bar, 30 μm.