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Model depicting potential roles of subunit D [4Fe-4S] clusters in modulating assembly and/or activity of M. acetivorans RNAP. The three domains of subunit D are represented by 1, 2, and 3. A change in the reduction state of each [4Fe-4S] cluster is indicated by a circle versus a square. The dashed semicircle arrow depicts the increased flexibility of domain 3 upon loss of the [4Fe-4S] clusters.
