FIGURE 2.

Schematic diagram with the sequences and the predicted secondary structures of the hTR constructs used in this study. A, engineered hTR pseudoknot constructs (PKWT and PKWT-1, top) and sequence of the template/pseudoknot domain (bottom) of hTR. Bases in blue font are non-native sequence. Capital letters correspond to residues ≥80% conserved in vertebrates. B, secondary structure model of hTR, adapted from Ref. 29, including a schematic representation of the different RNA constructs screened with the RIPtide platform.