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. 2011 Mar 25;32(3):422–440. doi: 10.1210/er.2011-0001

Fig. 4.

Fig. 4.

Model for a mechanism that restricts juvenile body growth. In early life, multiple growth-promoting genes are well expressed, leading to rapid growth. However, growth causes down-regulation of these growth-promoting genes (perhaps through epigenetic mechanisms) which causes growth to slow. Progression of this negative feedback loop would eventually cause the growth rate to approach zero.