Table 3.
Progression Free Survival - Univariated analysis | |||||
---|---|---|---|---|---|
HR | Lower 95% CI | Upper 95% CI | p-value | ||
Age at diagnosis | 1.04 | 1.00 | 1.07 | 0.024 | |
Stage | I | 1 | |||
II | 1.24 | 0.54 | 2.85 | 0.606 | |
Grading | G1 | 1 | |||
G2 | 1.95 | 0.63 | 5.97 | 0.245 | |
G3 | 2.63 | 0.89 | 7.77 | 0.081 | |
Histotype | Serous | 1 | |||
Endometroid | 0.46 | 0.17 | 1.26 | 0.132 | |
Clear cell | 1.15 | 0.49 | 2.71 | 0.756 | |
Mucinous | 0.59 | 0.17 | 2.04 | 0.404 | |
Undifferentiated | 6.88 | 1.46 | 32.37 | 0.01 | |
Other | 0.76 | 0.17 | 3.34 | 0.717 | |
First line therapy | No therapy | 1 | |||
Platinum-based | 0.79 | 0.40 | 1.58 | 0.510 | |
KRAS status | Wild-type | 1 | |||
Mutated | 0.85 | 0.33 | 2.19 | 0.736 | |
KRAS gene copy number | Disomy | 1 | |||
Amplification | 1.48 | 0.64 | 3.44 | 0.357 | |
Deletion | 1.22 | 0.37 | 4.04 | 0.748 | |
KRAS-LCS6 polymorphism | T/G-G/G | 1 | |||
T/T | 1.08 | 0.45 | 2.60 | 0.865 | |
Progression Free Survival - Multivariated analysis | |||||
HR | Lower 95% CI | Upper 95% CI | p-value | ||
KRAS-LCS6 polymorphism | T/G-G/G | 1 | |||
T/T | 1.34 | 0.50 | 3.57 | 0.564 |