Table 2.
Update on clinical trials for CSC mole targets
| Target | Drug | Cancer | Target | Phase | Date | Gov Identifier |
|---|---|---|---|---|---|---|
| Wnt | vitamin D3 | Basal Cell Carcinoma | β-catenin | III | 201109-201208 | NCT01358045 |
| PRI-724 | advanced solid tumors | CBP/β-catenin | I | 201102-201303 | NCT01302405 | |
| CWP232291 | AML | β-catenin | I | 201107-201212 | NCT01398462 | |
| Notch | MK0752 | Advanced BreastCancer | γ-secretase | I | 200504-201108 | NCT00106145 |
| RO4929097 | Lung Cancer | γ-secretase | II | 201009-201109 | NCT01193868 | |
| PF-03084014 | Leukemia | γ-secretase | I | 200906-201303 | NCT00878189 | |
| OMP-21M18 | Pancreatic Cancer | anti-DLL4 | I | 201008-201401 | NCT01189929 | |
| Hh | GDC-0449 | Solid tumors Colorectal | PTCH and/or | I | 200909-201709 | NCT00968981 |
| SMO | II | 200803-201009 | NCT00636610 | |||
| BMS-833923 | Basal cell | SMO | I | 200807-201312 | NCT00670189 | |
| IPI-926 | Primary Myelofibrosis Fibrosis, Bone Marrow | SMO | II | 201110-201305 | NCT01371617 |