Table 1.
Phase A | Phase B |
---|---|
A1: 0.1% TFA in water | B1: 0.1% TFA in acetonitrile |
A2: 0.1% TEA/AcOH (TEAA) in water (pH 6.0) | B2: 90% acetonitrile in Phase A2 (pH adjusted to 6.0 with AcOH) |
Method A: 10–40% Phase B1 in Phase A1 in 30 min; Method B: 10–60% Phase B1 in Phase A1 in 50 min; Method C: 10–90% Phase B1 in Phase A1 in 30 min; Method D: 20–60% Phase B1 in Phase A1 in 50 min; Method E: 10–60% Phase B2 in Phase A2 in 50 min; Method F: 10–90% Phase B2 in Phase A2 in 40 min