Skip to main content
. 2010 Mar 17;31(4):544–577. doi: 10.1210/er.2009-0023

Figure 4.

Figure 4

GnRH neuron firing activity correlates with LH levels in the daily LH surge mouse model. Representative examples of firing patterns in GnRH neurons recorded extracellularly from OVX (left) or OVX+E (right) mice in the morning (top) or evening (bottom). Vertical lines at the top of each graph indicate timing of individual action currents recorded from an individual GnRH neuron. The frequency of action current firing is plotted in 1-min bins for each cell. Cells from OVX mice show no diurnal difference in firing properties, whereas cells from OVX+E mice show low levels of activity in the morning (negative feedback) and higher levels of activity in the evening (positive feedback). [Data adapted from C. A. Christian et al.: Proc Natl Acad Sci USA 102:15682–15687 (49). © 2005, National Academy of Sciences, U.S.A.].