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Clock/Clock mutant mice fail to exhibit an LH surge on proestrus. A, Individual LH traces from wild-type (open circles) and Clock/Clock females (filled circles). White and black bars on x-axis represent times of lights on and lights off, respectively. B, Peak LH values obtained in wild-type and Clock/Clock female mice. *P < 0.01. [Data adapted from B. H. Miller et al.: Curr Biol 14:1367–1373 (20). © 2004, Elsevier].
