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. 2010 Mar 17;31(4):544–577. doi: 10.1210/er.2009-0023

Figure 9.

Figure 9

Estradiol decreases GABA transmission to GnRH neurons but increases it during the surge. A, Representative whole-cell voltage-clamp recordings of spontaneous GABAergic postsynaptic currents (sPSCs, downward deflections) in GnRH neurons from mice treated in the OVX+E daily surge model during negative feedback, surge onset, and surge peak. Recordings were performed in the presence of ionotropic glutamate receptor antagonists to isolate GABAergic currents. Note the increased frequency and amplitude of sPSCs during surge onset and peak compared with negative feedback. B, Mean ± sem of sPSC frequency in cells from OVX (open bars) and OVX+E (filled bars) mice during negative feedback, surge onset, and surge peak. *P < 0.05 vs. OVX. [Data adapted from C. A. Christian and S. M. Moenter: J Neurosci 27:1913–1921 (247). © 2007, Society for Neuroscience].