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. 2012 Jun 1;7(6):e38381. doi: 10.1371/journal.pone.0038381

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Yin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Normal structure of spinal cord was observed in the sham (A) and sham/TIIA (B) groups at 24 h after SCI. A significant damage of spinal cord was shown by the presence of edema, haemorrhage and loose structure tissue at 24 h after SCI (C). A significant protective effect of TIIA (20 mg/kg) was observed in the SCI/TIIA group (D). wm: white matter; gm: gray matter. The histological score was accessed in a blinded manner (E). MPO activity in tissues was significantly increased at 24 h in the SCI group compared with the sham and sham/TIIA groups and was decreased with the treatment of TIIA (F). Bars represent means ± SEM. **p<0.001 vs. sham group, ^# p<0.05 vs. SCI group.