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Average percent time spent in W, NR and REM in young and old rats following ICV infusions of saline, 10 μg and 30 μg of Hcrt-2 at ZT0. Panel A: W in young rats. Panel B: W in old rats. Panel C: NR in young rats. Panel D: NR in old rats. Panel E: REM in young rats. Panel F: REM saline in old rats. + = p<0.05 for 10 μg Hcrt-2 relative to vehicle; * = p<0.05 for 30 μg Hcrt-2 relative to vehicle.
