FIGURE 12.

Reduced KLF15 expression in human glomerular disease. A, immunostaining for KLF15 performed on healthy donor nephrectomy specimens shows a nuclear distribution in normal podocytes, parietal cells, and tubular cells. In comparison with biopsy specimen from healthy donor subjects (A), KLF15 expression in the podocytes is shown in biopsy specimens from patients with diagnosed HIVAN (B) and idiopathic FSGS (C). The representative images of three subjects in each group are shown. D, glomerular region was selected, and optical density (OD) was measured and quantified as a relative fold change to healthy donor specimens (n = 3, *, p < 0.0001).