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. 2012 Apr 9;287(23):19242–19254. doi: 10.1074/jbc.M112.349936

FIGURE 6.

FIGURE 6.

Ectopic expression of hMSH2 is inducible on human melanoma, lymphoma or leukemia cells. A, the level of IL-18 released into the supernatants of G401 and A375 cells was measured by ELISA (mean ± S.D. (error bars), n = 3 from three independent experiments). *, p < 0.05. B, ectopic expression of hMSH2 on the surface of A375, Jurkat, and K562 cells stimulated with GO for 36 h. The black lines represented surface expression of hMSH2 on GO-stimulated cells. Surface expression of hMSH2 on normal cultured cells is displayed as dotted lines, and the respective isotype controls are shown as solid gray. C, IL-18Rα expression on normal cultured A375, Jurkat, and K562 cells. D, ectopic expression of hMSH2 on IL-18 (100 ng/ml)-treated A375, Jurkat, and K562 cells. Shown are ectopic hMSH2 expressions on IL-18-treated tumor cells (black line), normal cultured tumor cells (dotted line), and the isotype controls (solid gray).