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. 2012 Apr 16;287(23):19516–19527. doi: 10.1074/jbc.M111.337428

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Correlation of PTTG1 expression with poor prognosis in breast cancer patients. A, tissue array containing breast cancer with normal counterpart tissues was immunostained with PTTG1 antibody. High expression levels of PTTG1 were shown in 9 of 11 cases of breast cancer tissues, compared with normal breast tissues. Representative images of three cases in normal breast tissues (upper) and breast cancer tissues (lower) are shown. Photomicrograph (×20 magnification) was taken by IX71 microscope (Olympus, Tokyo, Japan) equipped with DP71 digital imaging system (Olympus). B, Kaplan-Meier plot of human breast cancer patients using publicly available clinical breast cancer data. Breast cancer patients (2324) were grouped to high (1162) and low expression (1162) of PTTG1. Note that PTTG1 expression levels have strong correlation with poor prognosis and low survival rate.