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. 2012 Apr 19;287(23):19610–19621. doi: 10.1074/jbc.M112.344606

FIGURE 6.

FIGURE 6.

PI 3-kinase activation causes CdGAP plasma membrane recruitment. A and B, time-lapse series of COS-7 cells expressing GFP-CdGAP(R56AN169V) or GFP-CdGAP(17–1425). Serum-starved transfected COS-7 cells were treated with either DMSO or 50 μm LY294002 for 30 min before stimulation with 10 ng/ml PDGF. Scale bar, 5 μm. White arrowheads show membrane ruffles. C, quantification analysis of fixed cells, these values represent an average of three independent experiments, with at least 50 cells counted per condition and per experiment; error bars, S.E. *, p < 0.01 for the comparison to the control.