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. 2012 Apr 20;287(23):19665–19673. doi: 10.1074/jbc.M111.317214

FIGURE 2.

FIGURE 2.

A and B, overview of the chemical shift changes (Δδ) observed in 15N-labeled FKBP38(35–153) upon addition of a 3-fold molar excess of Bcl-2(119–131) (A), followed by the addition of a 2-fold molar excess of apo-CaM (B). C, CSP changes (Δδ) observed in 15N-labeled FKBP38(35–153) upon addition of a 3-fold molar excess of Bcl-2(119–131) R127Q/R129Q. The arrow in A indicates the location of the charge-sensitive β5-α1 loop (black ribbon) in the catalytic domain of FKBP38. The dashed line in A represents the mean CSP value + 1 S.D.