Table 1.
Effect of monocrotaline (MCT) and sodium nitrite treatment on pulmonary and systemic hemodynamic values.
| PAP, Systolic (mmHg) | PAP, Diastolic (mmHg) | PAP mean (mmHg) | PVR (mmHg/ml/min) | MAP (mmHg) | Cardiac Output (ml/min) | SVR (mmHg/ml/min) | |
|---|---|---|---|---|---|---|---|
| Control | 30 ± 2 | 9 ± 1 | 20 ± 0 | 0.18 ± 0.01 | 110 ± 5 | 105 ± 6 | 0.99 ± 0.07 |
| MCT | 86 ± 7* | 29 ± 4* | 54 ± 2* | 0.55 ± 0.04* | 99 ± 6 | 103 ± 7 | 1.06 ± 0.05 |
| MCT +NaNO2 3mg/kg | 42 ± 1*⧧ | 21 ± 3*⧧ | 33 ± 3*⧧ | 0.31 ± 0.02*⧧ | 99 ± 5 | 92 ± 7 | 0.93 ± 0.04 |
Values are expressed as mean ± SE.
denotes a P value < 0.05 when compared to control,
denotes a P value < 0.05 when compared to MCT n = 11, 9, and 11 for Control, monocrotlaine, and monocrotaline+ NaNO2 groups respectively.
PAP pulmonary arterial pressure, PVR pulmonary vascular resistance, MAP mean arterial pressure, SVR systemic vascular resistance.
Control rats received a saline injection via tail vein on day one. MCT rats received ip saline injections on day 14–35 as a control for ip NaNO2 injections.