Table 2.
Hormonal characteristics of the women exhibiting the four profiles determined by baseline DHEAS values and changes in subsequent annual DHEAS values (N=30)a.
| Characteristic | Baseline DHEAS Reference Profile 1 (N=30) | Baseline DHEAS < 1 SD of Mean Profile 2 (N=30) | Baseline DHEAS at Mean Profile 3 (N=30) | Baseline DHEAS > 1 SD of Mean Profile 4 (N=30) | p-value for overall subgroup difference |
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD, p profile 2 and 3) | Mean (SD) | Mean (SD, p profile 3 and 4) | ||
| Androstenedione (pg/mL) | 1515.1 (1174.0) | 973.2 (446.2, p=0.169) | 927.6 (350.6) | 1188.7 (344.7, p=0.210) | 0.19 |
| Androstenediol (pg/mL) | 865.4 (205.3) | 287.7 (139.1, p=0.117) | 703.6 (327.0) | 1023.8 (266.5, p=0.056) | < 0.0001 |
| DHEAS (ug/dL) | 144.6 (49.5) | 41.6 (14.1, p=0.004) | 112.2 (39.2) | 265.1 (44.3, p=0.001) | < 0.0001 |
| SHBG (nM) | 46.9 (17.6) | 48.7 (28.1, p=0.560) | 42.3 (22.8) | 32.2 (11.4, p=0.386) | 0.36 |
| Testosterone (ng/dL) | 61.7 (22.9) | 34.6 (23.9, p=0.553) | 51.0 (32.4) | 63.0 (24.1, p=8.828) | 0.008 |
| Estradiol (pg/mL) | 81.2 (36.3) | 79.9 (72.3, p=0.675) | 59.3 (49.4) | 66.4 (86.9, p=0.383) | 0.26 |
a
The Reference Profile shows a DHEAS fall in subsequent years, while Profiles 2–4 show a fall in the subsequent year and then rise. P values are provided to illustrate the significance between the mean (Profile 3) and < 1SD below the mean (Profile 2) and between the mean (Profile 3) and > 1SD above the mean (Profile 4).