Table 3.

Histologic and immunohistochemical criteria/features of serous tubal intraepithelial carcinoma in prior studies

Study*	Histology	Immunohistochemistry
Sehdev et al [23] (n=37)	See Przybycin et al (22) for histologic features	p53: Positive in 75% of cases (mean, 93% positive cells; range, 60–100%) Completely negative in 14% (corresponding to “0% labeling index”) Negative in 11% (corresponding to “wild-type” pattern) Ki-67 proliferation index: Mean, 38% positive cells (range, 2–90%)
Jarboe et al [3] (n=34)	Invariably present features: Discrete population of cells replacing tubal mucosa, increased nuclear-to-cytoplasmic ratio with round nuclei, loss of polarity, prominent nucleoli, and absence of ciliated cells Common but not invariably present features: Epithelial stratification, cleavage planes within the epithelium, and exfoliation of cell clusters	Specific p53 data not detailed Ki-67 proliferation index: Mean, 72% positive cells (range, 40–95%)
Przybycin et al [22] (n=28)	Main features: Loss of polarity, increased nuclear size, increased nuclear-to-cytoplasmic ratio, hyperchromasia, irregular nuclear membranes and chromatin distribution, mitotic figures, and loss of cilia Other features occasionally present: Epithelial stratification and nuclear molding	See Sehdev et al [23] for immunohistochemical features
Wei et al [8] (n=24)	≥20 consecutive neoplastic secretory cells (high-grade atypia and/or at least moderate atypia with intraepithelial proliferation [stratification, tufting, and papillae]) with or without p53 immunoreactivity	p53 expression in 71% of cases (exact extent of p53 staining not provided for positive cases) p53 negative in 29% of cases
Shaw et al [7] (n=17)	Stratification, increased nuclear size, nuclear pleomorphism, loss of polarity, and prominent nucleoli	Overexpression of p53 (>75% positive cells) present in majority of cases, and Ki-67 increased; however, specific Ki-67 proliferation indices not provided 24% of cases without p53 overexpression, but Ki-67 indices described as being sufficient for diagnosis of STIC
Salvador et al [16] (n=8)	Loss of cell polarity, increased nuclear-to-cell ratio, prominent nucleoli, and absence of ciliated cells	p53 immunohistochemical index: Low (≤50% positive cells) in 25% of cases High (>50% positive cells) in 75% Ki-67 proliferation index: Intermediate (6–50% positive cells) in 63% High (>50% positive cells) in 38%
Maeda et al [5] (n=7)	Malignant epithelial cells with pleomorphic nuclei, stratification, and loss of polarity	p53: Diffuse expression in 43% of cases Completely negative in 29% (corresponding to “0% labeling index”) Negative in 29% (corresponding to “wild-type” pattern) Ki-67 proliferation index: Mean, 39% positive cells (range, 9–72%)

Key:

^*Multiple studies from the same institution are listed only once except where noted above.