Table 2.
Summary of GWAS meta-analysis results with P < 5 × 10−8
| Discovery | Replication | Overall | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Locus | Closest gene |
SNP location relative to closest gene |
Minor/ major allele |
MAF (%) |
RR (95% CI) |
Meta P value |
I2 (%), P value |
RR (95% CI) |
Meta P value |
RR (95% CI) |
Meta P value |
| rs6666258 | 1q21 | KCNN3-PMVK | Intronic | C/G | 29.9 | 1.18 (1.13–1.23) | 2.0 × 10−14 | 42.3, 0.04 | – | – | – | – |
| rs3903239 | 1q24 | PRRX1 | 46 kb upstream | G/A | 44.7 | 1.14 (1.10–1.18) | 9.1 × 10−11 | 53.2, 6.3 × 10−3 | 1.13 (1.06–1.20) | 2.0 × 10−4 | 1.14 (1.10–1.17) | 8.4 × 10−14 |
| rs6817105 | 4q25 | PITX2 | 150 kb upstream | C/T | 13.1 | 1.64 (1.55–1.73) | 1.8 × 10−74 | 80.8, 1.4 × 10−10 | – | – | – | – |
| rs2040862 | 5q31 | WNT8A | Intronic | T/C | 17.8 | 1.15 (1.09–1.21) | 3.2 × 10−8 | 10, 0.34 | 1.04 (0.96–1.12) | 3.6 × 10−1 | 1.12 (1.07–1.17) | 2.5 × 10−7 |
| rs3807989 | 7q31 | CAV1 | Intronic | A/G | 40.4 | 0.88 (0.84–0.91) | 9.6 × 10−11 | 10, 0.34 | 0.93 (0.88–0.97) | 2.7 × 10−3 | 0.90 (0.87–0.92) | 3.6 × 10−12 |
| rs10821415 | 9q22 | C9orf3 | Intronic | A/C | 42.4 | 1.13 (1.08–1.18) | 7.9 × 10−9 | 49.5, 0.015 | 1.09 (1.04–1.15) | 7.2 × 10−4 | 1.11 (1.08–1.15) | 4.2 × 10−11 |
| rs10824026 | 10q22 | SYNPO2L | 5 kb upstream | G/A | 15.8 | 0.85 (0.81–0.90) | 1.7 × 10−8 | 37.9, 0.06 | 0.91 (0.83–0.99) | 3.5 × 10−2 | 0.87 (0.83–0.91) | 4.0 × 10−9 |
| rs1152591 | 14q23 | SYNE2 | Intronic | A/G | 47.6 | 1.13 (1.09–1.18) | 6.2 × 10−10 | 25.7, 0.16 | 1.12 (1.06–1.19) | 1.9 × 10−4 | 1.13 (1.09–1.17) | 5.8 × 10−13 |
| rs7164883 | 15q24 | HCN4 | Intronic | G/A | 16.0 | 1.16 (1.10–1.22) | 1.3 × 10−8 | 0, 0.85 | 1.24 (1.16–1.32) | 1.3 × 10−10 | 1.19 (1.14–1.24) | 2.8 × 10−17 |
| rs2106261 | 16q22 | ZFHX3 | Intronic | T/C | 17.6 | 1.24 (1.17–1.30) | 3.2 × 10−16 | 58.8, 1.6 × 10−3 | – | – | – | – |
MAF, minor allele frequency; RR, relative risk. I2 represents the proportion of variability in the effect size due to between-study variability. We did not attempt replication of the previously published genetic loci associated with atrial fibrillation on chromosomes 1q21 (KCNN3)2, 4q25 (PITX2)4 and 16q22 (ZFHX3)3,5.