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Pracinostat and pacritinib have synergistic effects on AML-induced plasma cytokines/growth factors/chemokines. Plasma levels of a panel of 32 cytokines/growth factors/chemokines were analyzed using the MAP Mouse Cytokine/Chemokine panel from Millipore. Plasma was collected from SCID-beige mice bearing s.c. SET-2 tumors on d18, 3 h post-dose, after chronic dosing with pacritinib and pracinostat from the mice used in the efficacy study described in Figure 4.
