Figure 2.

Neither loss of Bik, nor combined loss of Bik and Noxa accelerate lymphoma development in Eμ-Myc transgenic mice. (a) Kaplan–Meier survival analysis of mice of the indicated genotypes. Differences in tumour onset between Eμ-Myc (n=68), Eμ-Myc/Noxa^−/− (n=64), Eμ-Myc/Bik^−/− (n=30) and Eμ-Myc/Bik^−/−Noxa^−/− (n=27) mice were not significant (P=0.170, 0.433, 0.321, respectively compared with control Eμ-Myc). (b) Loss of BIK alone, or in combination with NOXA loss, in Eμ-Myc mice did not significantly alter the latency or incidence of either pre-B lymphomas (top panel; Eμ-Myc n=10, Eμ-Myc/Bik^−/− n=9, Eμ-Myc/Bik^−/−Noxa^−/− n=10) or B lymphomas (bottom panel; Eμ-Myc n=14, Eμ-Myc/Bik^−/− n=11, Eμ-Myc/Bik^−/−Noxa^−/− n=5) compared with those seen in Eμ-Myc mice