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. 1997 Apr 29;94(9):4239–4241. doi: 10.1073/pnas.94.9.4239

Figure 1.

Figure 1

Functional model for CREB as a molecular switch controlling the induction of LTM formation. (Top) When CREB activator(s) predominate over repressor(s), the CREB switch is “on” and LTM is induced after just one training session (which is normal for some tasks). (Middle) When CREB activator(s) and repressor(s) are equal, the CREB switch acts as an information filter and induction of LTM requires spaced training (which is the case for most tasks). (Bottom) When CREB repressor(s) predominate over activator(s), the CREB switch is “off” and LTM, even after spaced training, is blocked.