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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Feb 10;1819(7):684–687. doi: 10.1016/j.bbagrm.2012.02.002

Figure 1. Probing the p53 signaling pathway at a genome wide level.

Figure 1

p53 acts as a hub for many stress signals in cells. Once being activated, p53 is stabilized and subject to post-translational modifications. It also recruits co-factors, binds to chromatin and activates hundreds of downstream targets that include both protein-coding and noncoding RNAs. These downstream targets will elicit various cellular outcomes, such as cell cycle arrest, apoptosis, senescence and stem cell differentiation. A new generation of genome-wide approaches, such as ChIP-seq and RNA-seq, can measure high quality signals of chromatin binding, cofactor recruitment, post-translational modifications and p53-regulated targets.