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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Arthritis Rheum. 2012 Jul;64(7):2289–2299. doi: 10.1002/art.34411

Figure 1. WISP3/CCN6 expression in OA versus PM cartilage.

Figure 1

(A) Real time RT-PCR for WISP3/CCN6 on mRNA from PM cartilage (20 different post-mortem samples) and OA cartilage (18 different osteoarthritic samples). * = P < 0.001. (B–D) Immunohistochemical staining for WISP3/CCN6 protein in cartilage sections. (B) Top: Pericellular staining in extensively damaged OA cartilage. Bottom: No staining in undamaged PM cartilage. (C) No staining in undamaged cartilage (top) but staining in damaged cartilage (bottom) from the knee of an OA donor with focal cartilage damage. (D) No staining in undamaged (top) but diffuse staining in damaged (bottom) areas of partially damaged PM cartilage. Scale bar = 100μm.