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. Author manuscript; available in PMC: 2012 Jun 3.
Published in final edited form as: Proteins. 2007 Nov 1;69(2):270–284. doi: 10.1002/prot.21471

Figure 4. Cross-links of HIV-1 Vif.

Figure 4

Figure 4

Figure 4

Figure 4

Schematic diagram of cross-links observed in different oligomeric states of HIV-1 Vif that were analyzed by MALDI-TOF and heavy water labeling. (A) Consensus secondary structure prediction for HIV-1 Vif 52. Red: beta-sheet. Blue: alpha-helix. Purple: random coil (B) Cross-links observed in the monomer sample. (C) Cross-links observed in the dimer sample and shown going from both the N- to C-terminal and from the C-to N-terminal regions. (D) Cross-links observed in the trimer and shown going from both the N-to C-terminal and from the C- to N-terminal regions. Cross-linking: Dotted lines indicate that cross-links appeared in both the dimer and trimer samples. The blue bars represent peptide coverage for each oligomeric state.