Table 5.
Multivariate linear regression showing relationship between Hemoglobin SS group, angiogenic growth factors, and CPC populations. SDF-1α was consistently associated with the relationship between Hemoglobin SS status and all CPC types (highlighted). Significant reductions in the beta-coefficient (>25%) compared to the main exposure variable are marked with an asterisk (*).
| Outcome variables | ||||||||
|---|---|---|---|---|---|---|---|---|
| Exposure variables | CD34 | CD34/CXCR4 | CD34/VEGFR2 | CD34/CXCR4/VEGFR2 | ||||
| β | Adj r 2 | β | Adj r 2 | β | Adj r 2 | β | Adj r 2 | |
| Group = Hb SS | 0.94 | 0.19 | 1.24 | 0.28 | 1.45 | 0.29 | 1.06 | 0.14 |
| Hb SS + Erythropoietin | 0.57* | 0.16 | 0.51* | 0.29 | 1.44 | 0.25 | 1.02 | 0.1 |
| Hb SS + Angiopoietin-2 | 1.0 | 0.17 | 1.12 | 0.26 | 1.24 | 0.25 | 0.76* | 0.11 |
| Hb SS + SDF-1α | 0.54* | 0.18 | 0.68* | 0.3 | 1.0* | 0.27 | 0.37* | 0.15 |
| Hb SS + SDF-1α + Erythropoietin | 0.42* | 0.17 | 0.3* | 0.31 | 1.24 | 0.26 | 0.54* | 0.14 |
| Hb SS + SDF-1α + Angiopoietin-2 | 0.71 | 0.19 | 0.73* | 0.29 | 0.98* | 0.26 | 0.3* | 0.14 |