Figure 1.

Effect of LEM on hepatic injury in CCl₄-treated rats. All rats were received oral administration at indicated dose three times per day. (a) Normal rats treated with vehicle. (b) Normal rats treated with CCl₄ for 8 weeks. (c) CCl₄-treated rats received oral administration of silymarin (200 mg/kg) for 8 weeks. (d) CCl₄-treated rats received oral administration of LEM (100 mg/kg) for 8 weeks. (e) CCl₄-treated rats received oral administration of LEM (200 mg/kg) for 8 weeks. (f) CCl₄-treated rats received oral administration of LEM (500 mg/kg) for 8 weeks. Histology of liver was characterized by staining with hematoxylin-eosin (Magnification: ×400).