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. 2012 May 22;2012:231586. doi: 10.1100/2012/231586

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Copyright © 2012 Mei-Fen Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of LEM on gene expressions of Mn-SOD, Cu/Zn-SOD, and glutathione peroxidase (GPx) in liver of CCl₄-treated rats. (a) The representative picture showing mRNA levels for Mn-SOD, Cu/Zn-SOD, GPx, or β-actin in liver isolated from CCl₄-induced rats receiving treatment with silymarin or LEM three times daily for 8 weeks. Lane 1: vehicle-treated Wistar rats; lane 2: vehicle-treated CCl₄-induced rats; lane 3: silymarin- (200 mg/kg) treated CCl₄-induced rats; lane 4: LEM- (100 mg/kg) treated CCl₄-induced rats; lane 5: LEM- (200 mg/kg) treated CCl₄-induced rats; lane 6: LEM- (500 mg/kg) treated CCl₄-induced rats. (b) The representative response of protein level for Mn-SOD, Cu/Zn-SOD, GPx, or actin in liver isolated from CCl₄-induced rats receiving treatment with silymarin or LEM three times daily for 8 weeks. All lanes are expressed as the same as mRNA level (a) on the above.