Table 2.

Activities of cholesterol biosynthetic enzymes in liver and kidney of P0 control and Pex2^−/− mice on the 129 and SW/129 genetic background

Enzyme	Liver
	129		SW/129
	Control	Pex2−/−	Control	Pex2−/−
HMG-CoA reductase	254.3 ± 109.0 (12)	532.8 ± 127.5 (6) ***	189.9 ± 48.6 (4)	215.7 ± 21.6 (3)
IPP isomerase	2030.1 ± 541.4 (10)	3148.9 ± 648.4 (6) **	944.5 ± 154.9 (4)	1250.5 ± 125.0 (3)
FPP synthase	3051.2 ± 411.7 (10)	3328.1 ± 240.3 (7)	3400.4 ± 388.6 (4)	3768.5 ± 505.5 (3)
Squalene synthase	8.6 ± 4.4 (8)	17.6 ± 4.8 (5) **	11.9 ± 3.0 (4)	22.3 ± 4.0 (3)
Enzyme	Kidney
	129		SW/129
	Control	Pex2−/−	Control	Pex2−/−
HMG-CoA reductase	64.2 ± 21.5 (5)	33.1 ± 6.0 (5) *	81.1 ± 19.5 (6)	42.1 ± 8.7 (5) ***
IPP isomerase	421.0 ± 40.8 (3)	396.7 ± 83.8 (3)	447.1 ± 27.3 (6)	444.9 ± 59.7 (5)
FPP synthase	587.5 ± 37.4 (7)	524.8 ± 53.9 (5)	624.7 ± 81.4 (6)	549.0 ± 76.3 (5)
Squalene synthase	2.01 ± 0.74 (7)	1.30 ± 0.44 (5)	4.56 ± 0.31 (3)	3.77 ± 0.27 (3) *

Each value represents the mean ± S.D. of the activities expressed as pmol/min/mg protein (n = number of samples). Enzyme activities from wild-type and heterozygous mice were similar and combined (control mice).

^*, P < 0.05;

^**, P < 0.005;

^***P < 0.001 denote the level of statistical significance (Student’s t-test). Activities of cholesterol biosynthetic enzymes in liver of P0 mice on the SW/129 genetic background are reproduced, with permission, from Kovacs et al. [14], © American Society for Microbiology [Mol. Cell. Biol., 2004; 24: 1–13.]