. 2012 May;26(5):274–280. doi: 10.1089/apc.2011.0196

Table 3.

Adjusted^a Hazard Ratios Highlighting the Effect of Age (per 10 Years Younger) on Time to Viral Load Suppression in Cox Proportional Hazards Regression Models

Model	HR (95% CI)	p Value
Effect of age, without adherence (mediator) variable included	0.75 (0.64–0.88)	<0.001
Effect of age, including adherence (mediator) variable^b	0.85 (0.72–1.01)	0.06

^{^a}

Additionally adjusted for baseline CD4⁺ count (AHR, 0.90 for each increase of 100 cells per microliter; 95% CI, 0.84–0.97 in model with adherence) and viral load (AHR, 0.55 for each log₁₀ decrease in counts per milliliter; 95% CI, 0.44–0.69 in model with adherence).

^{^b}

Sobel test for mediation: statistic, 3.08; p=0.002.

HR, hazard ratio; CI, confidence interval.