Figure 1. The relationship between duration of the disease, (left panel) concentration, and (right panel) conformational stability of sPrP^Sc conformers in sCJD patients with different WB patterns and PRNP gene polymorphisms.⁹² The stability of PrPSc was determined with CDI before and after protease treatment and the change is expressed as ΔGdn HCl_1/2.⁹² The symbols are mean ± SEM in each sCJD group.