Fig. 2.

Theoretical targets of organophosphates on proteins involved in axonal transport. Anterograde axonal transport (i.e., transport in the direction from the cell body to the synaptic terminal) is carried out by the motor protein kinesin while retrograde transport (from synaptic terminals to the cell body) is primarily carried out by cytoplasmic dynein. Tubulin polymerizes to form microtubules which serve a fundamental role as structural (cytoskeletal) components within neurons and they also function as substrates (or rails) along which motor proteins move.