Fig. 4.

Theoretical targets of organophosphates on mitochondrial function. OPs have been observed in neuronal culture to increase mitochondrial length and to decrease mitochondrial number (indicative of increased fusion versus fission events, see top of figure). OPs have also been observed to decrease the transport of mitochondria in axons (middle of figure) as well as to increase oxidative stress and promote mitochondrial-dependent apoptotic processes (bottom of figure).