Figure 2. TLR2 from immune cells is required for Y. pseudotuberculosis disruption of PP barrier function.

(A and B) PPs from chimeric mice, expressing TLR-2 (+/+) or not (–/–) in epithelial and immune cells, were mounted in UCs and incubated with pIB102, and (A) paracellular permeability and (B) fluorescent E. coli K-12 translocation were monitored. n = 6 per group; 2 independent experiments. *P < 0.05, ***P < 0.001 versus uninfected +/+ → +/+; ^†P < 0.05, ^††P < 0.01 versus pIB102-infected –/– → +/+.