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. 2012 May 8;122(6):2239–2251. doi: 10.1172/JCI58147

Figure 3. Increased IL-1β expression triggered by Y. pseudotuberculosis is mediated by TLR-2.

Figure 3

(A and B) WT, Tlr2–/–, and Myd88–/– mice were inoculated i.g. with pIB102 and killed 5 days after infection. PPs (A) and spleens (B) were removed, and IL-1β levels were analyzed. (C) PPs from chimeric mice were incubated with pIB102 in UCs. (D and E) BMSCs from WT, Tlr2–/–, and Myd88–/– mice were differentiated into macrophages (D) or DCs (E) and infected with pIB102. IL-1β level in the supernatant was then analyzed by ELISA. n ≥ 6 per group; 3 independent experiments. **P < 0.01, ***P < 0.001 versus uninfected WT; †P < 0.05, ††P < 0.01, †††P < 0.001 versus pIB102-infected WT; ##P < 0.01 versus pIB102-infected +/+ → +/+.