Figure 7. NKT/IL-15 cells have potent antitumor activity in a metastatic NB model in hu-NSG mice.
At 3 months after SCT, hu-NSG or control NSG mice received i.v. injection of 106 CHLA-255/luc NB cells alone or followed by 107 NKT or NKT/IL-15 cells. Metastatic tumor growth was monitored by weekly bioluminescence imaging. (A) Representative bioluminescent images at the indicated times after tumor cell injection. (B) Mean ± SD values from of 1 of 2 experiments with 5 mice per group. ***P < 0.001. (C) Mice were pretreated with anti-CD1d blocking or isotype control mAb before transfer of NKT/IL-15 cells. Shown are mean ± SD values at week 5 from of 1 of 2 experiments with 5 mice per group. *P < 0.05; ***P < 0.001.