Figure 3. S6 mice express two renin isoforms, while B6 mice express one renin isoform.

mRNAs encoding renin 1 (A) and renin 2 (B) were measured via qRT-PCR in kidneys of male WT and sGCα₁^–/– mice on the S6 or B6 genetic background. n = 10–15/group. No significant differences in renin 1 mRNA levels were found between WT and sGCα₁^–/– mice on either background. mRNA levels of renin 2 were similar in WT and sGCα₁^–/– mice on the S6 genetic background, and were undetectable in WT and sGCα₁^–/– mice on the B6 genetic background. *P < 0.001 versus S6.