Figure 6. RAAS inhibition normalizes blood pressure in sGCα₁^–/–S6 mice.

(A) MAP, measured invasively in anesthetized male WT and sGCα₁^–/– mice on the 129S6 background treated with vehicle (n = 8 and 6, respectively) or aliskiren (n = 5 and 8, respectively). *P < 0.001 versus WT vehicle; ^†P < 0.001 versus sGCα₁^–/– vehicle. (B) MAP in male WT and sGCα₁^–/– mice on the 129S6 background treated with vehicle (n = 5 and 8, respectively) or spironolactone (n = 5 and 12, respectively). *P < 0.01 versus WT vehicle; ^†P < 0.001 versus sGCα₁^–/– vehicle.