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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Invest Dermatol. 2011 Sep;131(9):1785–1786. doi: 10.1038/jid.2011.200

Figure 1. The regulatory cell continuum mediates psoriatic pathogenesis.

Figure 1

Foxp3 T regulatory cells (Tregs) convert progressively to IL-17-producing regulatory cells driven by psoriatic cytokines, predominantly IL-23. The fine balance between the Treg master regulatory Foxp3 and RORγt controls the cellular fate of Tregs.