TABLE 1.

Classification of definite, probable, and possible NS¹⁵

NS can be diagnosed in patients with (i) a clinical presentation suggestive of NS with (ii) exclusion of other possible diagnoses, as follows:

Definite NS: Positive central nervous system histology Probable NS: [a] Laboratory evidence of CNS inflammation (elevated levels of CSF protein and/or cells, the presence of oligoclonal bands and/or MRI evidence compatible with neurosarcoidosis), and [b] Evidence for systemic sarcoidosis (either through positive histology, including Kveim test, and/or at least two indirect indicators from Gallium scan, chest imaging and serum ACE) Possible NS: Where the above criteria are not met

Abbreviations—NS: neurosarcoidosis; CNS: central nervous system; CSF: cerebrospinal fluid; MRI: magnetic resonance imaging; ACE: angiotensin converting enzyme